Tramadol as 1st-line therapy for OA linked to greater mortality

Treating osteoarthritis in older patients with tramadol, which binds µ-, δ-, and κ- opioid receptors with low affinity, and acts as an inhibitor of norepinephrine and serotonin reuptake, can be linked to more mortality in the year after treatment initiation, 4 Boston and 1 chinese research institutions found.