In this cross-sectional study of 422, 605 unintentional US deaths due to opioid toxicity, years of life lost more than tripled: from 777 ,597 to 2 ,922, 497 between 2011- 2021. By 2021, 1 of every 22 deaths was attributable to unintentional opioid toxicity. See also: Illicitly manufactured fentanyl-involved overdose deaths with detected Xylazine.


